Jean-Pierre HUGOT

Pediatrician and researcher, specialist of the intestinal inflammation

Université Paris Diderot
intestinal inflammation

Bio :

Jean-Pierre Hugot's researches concern the genetics of the intestinal inflammatory diseases. During hiS scientific research, he locates the first gene of susceptibility in the deCrohn disease in 1996, through an approach of positional cloning. It is one of the very first genes of complex diseases highlighted by this approach. In 2001, he  identified this gene. It is about NOD2 (also conscript CARD15), who codes an intracellular receiver for products of degradation of the bacterial walls. This work allowed to show that the disease of Crohn is associated with a deficit of the innate immunity.

Personal page :

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